Background: Alveolar bone defects in children still have a high incidence. Conventional bone graft technique that has been used as a defect therapy is still not effective. so new techniques with tissue engineering approach are needed. Bone Morphogenetic Protein 4 (BMP4) as one of the indicators of osteogenic differentiation has not been widely studied. https://macorners.shop/product-category/acrylic-first-day-of-school-sign/